A mother-of-pearl mosaic box is a decorative box typically made with a surface adorned with mother-of-pearl tiles or inlays. Mother-of-pearl is the iridescent inner layer of certain mollusk shells, prized for its beautiful luster and rainbow-like colors. Craftsmen often use small pieces of mother-of-pearl to create intricate patterns or designs on various objects, including boxes.

These boxes can serve as elegant jewelry boxes, keepsake boxes, or simply as decorative pieces. They are often handmade and can be found in various sizes and shapes, featuring different designs ranging from geometric patterns to floral motifs. The delicate and shimmering appearance of mother-of-pearl adds a touch of luxury to any space, making these boxes highly sought after for both their aesthetic appeal and practical use.